Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates

A Comprehensive snRNA-seq Atlas of the Primate Amygdala. Welcome to the interactive single-nucleus RNA-sequencing (snRNA-seq) atlas of the primate amygdala. This open-access resource delineates the complex neuronal organization of major amygdala subdivisions across humans, macaques, and baboons, providing a foundational tool for understanding primate brain architecture and its role in psychiatric disorders.

Key Features of the Atlas:

• Cross-Species Integration: Compares cellular profiles across human and nonhuman primates (NHPs), quantifying overlaps with established rodent, macaque, and human datasets.

• High-Resolution Cell Typing: Identifies five broad classes of excitatory neurons and diverse inhibitory populations (MGE, CGE, and LGE origins), highlighting substantial spatial variation across the amygdala.

• Validated Marker Genes: Features robust, subdivision-specific excitatory marker genes conserved across primate species, validated via fluorescence in situ hybridization (FISH).

To promote collaboration within the broader neuroscience community, all data, code, and cloud-based exploration tools are freely accessible below.